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A hallmark hormonal change during perimenopause is the gradual decline and fluctuation of ovarian hormones, particularly estrogen (E2) and progesterone (3)

Tesfaye S, Selvarajah D

Menon et al., 2019), the noradrenergic locus caeruleus neurons have been shown to exhibit a circadian rhythm with a maximum impulse activity during the period of vigilance (Gonzlez and Aston-Jones, 2006)

If daytime energy or focus is still lagging, NAD+ can step in by improving mitochondrial function and supporting the cellular energy production that keeps you going through the day

Sections were then washed three times with PBS and incubated with FITC-conjugated goat anti-rabbit IgG (Bioss) for 2 h at room temperature, after which the slices were stained with DAPI for 10 min